|
Medicinal Chemistry ::
This department utilizes highly advanced synthetic
and organic technologies for the synthesis of
intermediates, bulk pharmaceuticals up to commercial
scale production. They also carry out activities
such as design and synthesis of patentable New
Chemical Entities - NCEs using the sophisticated
Computer Aided Drug Design (CADD). Discovery Research
is carried out in the therapeutic areas like cardiovascular,
metabolic disorders, cerebro-vascular disorders
etc.
Medicinal chemistry at Torrent Research Centre
took-off as a small "Chemical Synthesis Group"
in 1992 and emerged as an established department
in 1994. The department took up Discovery Research
in 1995 with proven skills of process development.
Custom Synthesis for Target Compounds
:
Medicinal Chemistry synthesizes compounds which
accurately meet the Research Centre's requirements,
by utilizing a variety of highly advanced synthetic
organic technologies it has cultivated in the
speciality chemical field. It also meets the need
of commercial-scale production by combining various
support technologies and offering services that
are fully satisfactory in terms of cost, delivery
time and reliability.
Efficient synthetic methodologies of target molecules
for custom synthesis are developed by studying
synthetic pathways, evaluating process simulation,
designing new patentable routes and realising
the same routes at the laboratory.
Medicinal Chemistry employs the following
technologies :
| Basic
Technologies » |
- Condesation
- Halogenation
- Nitration
- Sulfonation
- Alkylation
- Diazotization
- Hydrogenation
- Oxidation
- Reduction
|
| Key
Technologies » |
- Reductive N-Alkylation
- Grignard Reaction
|
Technologies
for
Chiral Chemicals » |
- Asymmetric Synthesis
- Enzymatic Reaction & Resolution
- Optional Resolution
|
| Support
Technologies » |
- Analysis
- Safety Control
- Toxicology Assessment
- Process Safety Assessment
|
Technologies for Organic Synthesis :
The department has continuously improved its
technologies for synthesizing various biologically
active organic compounds/intermediates by combining
a wide range of organic synthetic technologies;
it accomplishes the synthesis of target compounds
quickly and efficiently.
Design & Development of NCE's :
Medicinal Chemistry has formed a research organization
that strongly propels research forward through
the cooperation of seven groups.
Pharmaceutical Ingredients and intermediates
in the past. Some of these are:
Active Pharmaceutical Ingredients :
- Sotalol : Optical Resolution
- Atenolol
- Diltiazem hydrochloride
- Amlodipine besylate
- Nicorandil
- Sulbactam
- Sultamicillin tosylate
- Norfloxacin
- Pefloxacin mesylate
- Lomefloxacin hydrochloride
- Sparfloxacin
- Ciprofloxacin hydrochloride
- Azithromycin
- Ketoconazole
- Fluconazole
- Albendazole
- Omeprazole
- Chlorhexidine base
- Lamotrigine
- Sertraline hydrochloride
- Ondansetron
- Sildenafil citrate
- Troglitazone
- Rosiglitazone
- Repaglinide
- Centchroman
- Bimoclomol
- Sibutramine hydrochloride hydrate
- Clopidogrel bisulphate
- Tegaserod maleate
- Moxifloxacin hydrochloride
- Ziprasidone hydrochloride
- Mosapride citrate
- Rabeprazole
- Zaleplon
- Leflunomide
- Esomeprozole
- Topiramate
Intermidiates :
- Diltiazem intermediates viz. D(+) Acid, cis-lactam
-
Ketoconazole intermediate
viz.[cis-(2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl)methyl
methanesulfonate]
-
Albendazole intermediate
viz. 4-propylthio-1,2-benzenediamine
-
Omeprazole intermediate viz.2-hydroxymethyl-3,5-dimethyl-4-methoxypyridine
- o-Benzoylbenzoic acid
- 2-Bromo-6-methoxynaphthalene
- Trimethylsulfoxonium iodide
- 2-4 - Thiazolindinedione
- 2 - Propionic acid, 3-(Dimethylamino) ethylester
(E)
Process Patents filed in India/PCT
and designated countries/USA: 30
Patented Granted in India &
US: 6
Patent filed in Discovery Research
in India/PCT & designated countries/USA: 123
Patents Granted in India &
US: 8
|
