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Home  ::  Research & Development  ::  Departments  ::  Development :: Medicinal Chemistry  
 

 

Medicinal Chemistry ::

This department utilizes highly advanced synthetic and organic technologies for the synthesis of intermediates, bulk pharmaceuticals up to commercial scale production.

Medicinal chemistry at Torrent R&D Centre took-off as a small "Chemical Synthesis Group" in 1992 and emerged as an established department in 1994. The department took up Discovery Research in 1995 with proven skills of process development.

Custom Synthesis for Target Compounds :

Medicinal Chemistry synthesizes compounds which accurately meet the our R&D Centre’s requirements, by utilizing a variety of highly advanced synthetic organic technologies it has cultivated in the speciality chemical field. It also meets the need of commercial-scale production by combining various support technologies and offering services that are fully satisfactory in terms of cost, delivery time and reliability. Efficient synthetic methodologies of target molecules for custom synthesis are developed by studying synthetic pathways, evaluating process simulation, designing new patentable routes and realising the same routes at the laboratory.

Medicinal Chemistry employs the following technologies :

Basic Technologies »
  • Condesation
  • Halogenation
  • Nitration
  • Sulfonation
  • Alkylation
  • Diazotization
  • Hydrogenation
  • Oxidation
  • Reduction
Key Technologies »
  • Reductive N-Alkylation
  • Grignard Reaction
Technologies for
Chiral Chemicals »
  • Asymmetric Synthesis
  • Enzymatic Reaction & Resolution
  • Optional Resolution
Support Technologies »
  • Analysis
  • Safety Control
  • Toxicology Assessment
  • Process Safety Assessment

Technologies for Organic Synthesis :

The department has continuously improved its technologies for synthesizing various biologically active organic compounds/intermediates by combining a wide range of organic synthetic technologies; it accomplishes the synthesis of target compounds quickly and efficiently.

Pharmaceutical Ingredients and intermediates in the past. Some of these are:

Active Pharmaceutical Ingredients:
•  Sotalol : Optical Resolution
•  Atenolol
•  Diltiazem hydrochloride
•  Amlodipine besylate
•  Nicorandil
•  Sulbactam
•  Sultamicillin tosylate
•  Norfloxacin
•  Pefloxacin mesylate
•  Lomefloxacin hydrochloride
•  Sparfloxacin
•  Ciprofloxacin hydrochloride
•  Azithromycin
•  Ketoconazole
•  Fluconazole
•  Albendazole
•  Omeprazole
•  Chlorhexidine base
•  Lamotrigine
•  Sertraline hydrochloride
•  Ondansetron
•  Sildenafil citrate
•  Troglitazone
•  Rosiglitazone
•  Repaglinide
•  Centchroman
•  Bimoclomol
•  Sibutramine hydrochloride hydrate
•  Clopidogrel bisulphate
•  Tegaserod maleate
•  Moxifloxacin hydrochloride
•  Ziprasidone hydrochloride
•  Mosapride citrate
•  Rabeprazole Zaleplon
•  Leflunomide
•  Esomeprozole
•  Topiramate

Intermidiates :

Diltiazem intermediates viz. D(+) Acid, cis-lactam
Ketoconazole intermediate viz.[cis-(2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl)methyl methanesulfonate]
Albendazole intermediate viz. 4-propylthio-1,2-benzenediamine
Omeprazole intermediate viz.2-hydroxymethyl-3,5-dimethyl-4-methoxypyridine
o-Benzoylbenzoic acid
2-Bromo-6-methoxynaphthalene
Trimethylsulfoxonium iodide
2-4 - Thiazolindinedione
2 - Propionic acid, 3-(Dimethylamino) ethylester (E)


Process Patents filed in India/PCT and designated countries/USA: 30

Patented Granted in India & US: 6


 
 
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