Research & Development - Intellectual Capital

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Intellectual Capital ::

Torrent believes that its human capital in the basis of its development. Torrent R&D Centre, begun by few scientists, is today manned by over 600 scientists with a combined experience of over 3000 scientific man-years in Drug Discovery and Development.

Today, our R&D Centre has transformed into a training ground for many new young scientists. Its rich human capital coupled with high-tech equipments gives it a cutting edge in the field of research and development. Efforts are on to provide scientists with opportunities to develop their capabilities further through training.

Select Patents:

1.	(US6624178) Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof
2.	(US6608094) Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof
3.	(US 6462057) Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof
4.	(US7223777) Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic and cosmetic uses thereof
5.	(WO/2008/149379) Novel compounds

Select Publications:

1.	TRC4186, a Novel AGE-breaker, Improves Diabetic Cardiomyopathy and Nephropathy in Ob-ZSF1 Model of Type 2 Diabetes; Journal of Cardiovascular Pharmacology: July 2009 - Volume 54 - Issue 1 - pp 72-81; Pathak, Padmaja; Gupta, Ramesh C; Chauthaiwale, Vijay; Dutt, Chaitanya; Joshi, Deepa; Gupta, Ram; Dubey, Amita; Shiwalkar, Ajay
2.	Phase I clinical studies of the advanced glycation end-product (AGE)-breaker TRC4186: safety, tolerability and pharmacokinetics in healthy subjects; Clin Drug Investig. 2009;29(9):559-75; Chandra KP, Shiwalkar A, Kotecha J, Thakkar P, Srivastava A, Chauthaiwale V, Sharma SK, Cross MR, Dutt C
3.	Continuous, non-invasive measurement of the haemodynamic response to submaximal exercise in patients with diabetes mellitus. Evidence of impaired cardiac reserve and peripheral vascular response; Heart. Published Online First: 22 October 2009; Deepa Joshi1, Ajay Shiwalkar, Maurice Cross, Sanjay Sharma, Ashish Vachhani, Chaitanya Dutt
4.	TRC4149 a novel advanced glycation end product breaker improves hemodynamic status in diabetic spontaneously hypertensive rats; European Joural of Medical Research, 2008 Aug 18;13(8):388-98; Pathak P, Gupta R, Chaudhari A, Shiwalkar A, Dubey A, Mandhare AB, Gupta RC, Joshi D, Chauthaiwale V.
5.	Synthesis of spiro[chroman-2,4'-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors; Bioorganic & Medicinal Chemistry Letters, 2009 Feb 1;19(3):949-53. Epub 2008 Dec 3; Shinde P, Srivastava SK, Odedara R, Tuli D, Munshi S, Patel J, Zambad SP, Sonawane R, Gupta RC, Chauthaiwale V, Dutt C.
6.	Novel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor; Bioorganic & Medicinal Chemistry Letters, 2009 Sep 1;19(17):5021-5. Epub 2009 Jul 12; Gupta RC, Chhipa L, Mandhare AB, Zambad SP, Chauthaiwale V, Nadkarni SS, Dutt C.